[111In]DOTA-NOC-ATE   Click here for help

GtoPdb Ligand ID: 2064

Synonyms: [111In-DOTA]-NOC-ATE [1] | [InIII-DOTA]-NOC-ATE | [InIII-DOTA]-NOC-ATE
 Ligand is labelled  Ligand is radioactive
Comment: Synthetic radiolabelled peptide. The amino acid sequence of octreotide (SMS 201,995) is modified by replacing the phenylalanine residue at position 3 and C-terminal threoninol with benzoyl-3-thienylalanine and threonine respectively. The peptide is conjugated with DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) and radiolabelled with indium (111I). The structure of the non-radiolabelled version of this ligand is shown in the reference.
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1. Ginj M, Chen J, Walter MA, Eltschinger V, Reubi JC, Maecke HR. (2005)
Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy.
Clin Cancer Res, 11 (3): 1136-45. [PMID:15709181]