[111In]DOTA-NOC-ATE   Click here for help

GtoPdb Ligand ID: 2064

Synonyms: [111In-DOTA]-NOC-ATE [1] | [InIII-DOTA]-NOC-ATE | [InIII-DOTA]-NOC-ATE
 Ligand is labelled  Ligand is radioactive
Comment: Synthetic radiolabelled peptide. The amino acid sequence of octreotide (SMS 201,995) is modified by replacing the phenylalanine residue at position 3 and C-terminal threoninol with benzoyl-3-thienylalanine and threonine respectively. The peptide is conjugated with DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) and radiolabelled with indium (111I). The structure of the non-radiolabelled version of this ligand is shown in the reference.
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST2 receptor Hs Agonist Full agonist 8.7 pIC50 - 1
pIC50 8.7 [1]
SST5 receptor Hs Agonist Full agonist 8.4 pIC50 - 1
pIC50 8.4 [1]
SST3 receptor Hs Agonist Full agonist 7.9 pIC50 - 1
pIC50 7.9 [1]