2-methyl-5-HT

Ligand id: 218

Name: 2-methyl-5-HT

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 62.04
Molecular weight 190.11
XLogP 1.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Proc. Natl. Acad. Sci. U.S.A., 90 (2): 408-12. [PMID:8380639]
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Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.
Mol. Pharmacol., 48 (6): 1054-62. [PMID:8848005]
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Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.
Neuropharmacology, 36 (4-5): 713-20. [PMID:9225298]
4. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF. (1999)
The 5-HT3B subunit is a major determinant of serotonin-receptor function.
Nature, 397 (6717): 359-63. [PMID:9950429]
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Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells.
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Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.
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Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig.
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8. Leysen JE, Gommeren W, Heylen L, Luyten WH, Van de Weyer I, Vanhoenacker P, Haegeman G, Schotte A, Van Gompel P, Wouters R et al.. (1996)
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.
Mol. Pharmacol., 50 (6): 1567-80. [PMID:8967979]
9. Miyake A, Mochizuki S, Takemoto Y, Akuzawa S. (1995)
Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.
Mol. Pharmacol., 48 (3): 407-16. [PMID:7565620]
10. Wainscott DB, Cohen ML, Schenck KW, Audia JE, Nissen JS, Baez M, Kursar JD, Lucaites VL, Nelson DL. (1993)
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Mol. Pharmacol., 43 (3): 419-26. [PMID:8450835]
11. Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR. (1992)
Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
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