DC-EBIO   Click here for help

GtoPdb Ligand ID: 2324

Synonyms: dichloro-EBIO
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 37.79
Molecular weight 230
XLogP 2.27
No. Lipinski's rules broken 0
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Canonical SMILES CCn1c(=O)[nH]c2c1cc(Cl)c(c2)Cl
Isomeric SMILES CCn1c(=O)[nH]c2c1cc(Cl)c(c2)Cl
InChI InChI=1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)
1. Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M. (2005)
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
J Biol Chem, 280 (50): 41404-11. [PMID:16239218]
2. Singh S, Syme CA, Singh AK, Devor DC, Bridges RJ. (2001)
Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
J Pharmacol Exp Ther, 296 (2): 600-11. [PMID:11160649]
3. Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V. (2007)
Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.
Curr Med Chem, 14 (13): 1437-57. [PMID:17584055]