charybdotoxin   Click here for help

GtoPdb Ligand ID: 2328

Synonyms: ChTX
Comment: From Leiurus quinquestriatus hebraeus (Yellow scorpion)
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1. Attali B, Romey G, Honoré E, Schmid-Alliana A, Mattéi MG, Lesage F, Ricard P, Barhanin J, Lazdunski M. (1992)
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
J Biol Chem, 267 (12): 8650-7. [PMID:1373731]
2. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. (2000)
Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.
J Biol Chem, 275 (47): 37137-49. [PMID:10961988]
3. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol Pharmacol, 45 (6): 1227-34. [PMID:7517498]
4. Grupe A, Schröter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S, Pongs O. (1990)
Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.
EMBO J, 9 (6): 1749-56. [PMID:2347305]
5. Jensen BS, Strobaek D, Christophersen P, Jorgensen TD, Hansen C, Silahtaroglu A, Olesen SP, Ahring PK. (1998)
Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.
Am J Physiol, 275 (3): C848-56. [PMID:9730970]
6. Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. (1997)
hSK4, a member of a novel subfamily of calcium-activated potassium channels.
Proc Natl Acad Sci USA, 94 (20): 11013-8. [PMID:9380751]
7. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. (2000)
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.
Am J Physiol Renal Physiol, 278 (6): F1013-21. [PMID:10836990]
8. Sands SB, Lewis RS, Cahalan MD. (1989)
Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes.
J Gen Physiol, 93 (6): 1061-74. [PMID:2475579]