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Abbreviated name: PMA
Synonyms: 12-O-tetradecanoylphorbol-13-acetate | tetradecanoyl-β-phorbol acetate | TPA
Compound class: Synthetic organic
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Mao J, Wang X, Chen F, Wang R, Rojas A, Shi Y, Piao H, Jiang C. (2004)
Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
Proc. Natl. Acad. Sci. U.S.A., 101 (4): 1087-92. [PMID:14732702]
2. Santi CM, Ferreira G, Yang B, Gazula VR, Butler A, Wei A, Kaczmarek LK, Salkoff L. (2006)
Opposite regulation of Slick and Slack K+ channels by neuromodulators.
J. Neurosci., 26 (19): 5059-68. [PMID:16687497]
3. Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J et al.. (2002)
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
J. Biol. Chem., 277 (16): 13569-77. [PMID:11827975]
4. Xu F, Satoh E, Iijima T. (2003)
Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.
Br. J. Pharmacol., 140 (2): 413-21. [PMID:12970074]