calmodulin   Click here for help

GtoPdb Ligand ID: 2351

Synonyms: Ca2+/calmodulin | Ca2+/CaM | calcium-calmodulin | CaM
Compound class: Endogenous peptide in human, mouse or rat
Comment: Consists of endogenous peptide calmodulin in complex with up to 4 calcium ions. The name 'calmodulin' is an abbreviation of 'calcium-modulated protein'.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J. (1994)
Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.
J Biol Chem, 269 (16): 12190-5. [PMID:8163524]
2. Chen TY, Yau KW. (1994)
Direct modulation by Ca(2+)-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons.
Nature, 368 (6471): 545-8. [PMID:7511217]
3. Choi EJ, Xia Z, Storm DR. (1992)
Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin.
Biochemistry, 31 (28): 6492-8. [PMID:1633161]
4. Hathaway DR, Adelstein RS. (1979)
Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity.
Proc Natl Acad Sci USA, 76 (4): 1653-7. [PMID:156362]
5. Jacobowitz O, Chen J, Premont RT, Iyengar R. (1993)
Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment.
J Biol Chem, 268 (6): 3829-32. [PMID:8440678]
6. Liu M, Chen TY, Ahamed B, Li J, Yau KW. (1994)
Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel.
Science, 266 (5189): 1348-54. [PMID:7526466]
7. Sallese M, Mariggiò S, Collodel G, Moretti E, Piomboni P, Baccetti B, De Blasi A. (1997)
G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells.
J Biol Chem, 272 (15): 10188-95. [PMID:9092566]
8. Stansfeld CE, Röper J, Ludwig J, Weseloh RM, Marsh SJ, Brown DA, Pongs O. (1996)
Elevation of intracellular calcium by muscarinic receptor activation induces a block of voltage-activated rat ether-à-go-go channels in a stably transfected cell line.
Proc Natl Acad Sci USA, 93 (18): 9910-4. [PMID:8790430]
9. Tang WJ, Krupinski J, Gilman AG. (1991)
Expression and characterization of calmodulin-activated (type I) adenylylcyclase.
J Biol Chem, 266 (13): 8595-603. [PMID:2022671]