calmodulin   Click here for help

GtoPdb Ligand ID: 2351

Synonyms: Ca2+/calmodulin | Ca2+/CaM | calcium-calmodulin | CaM
Compound class: Endogenous peptide in human, mouse or rat
Comment: Consists of endogenous peptide calmodulin in complex with up to 4 calcium ions. The name 'calmodulin' is an abbreviation of 'calcium-modulated protein'.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
Calmodulin-dependent kinase II
myosin light chain kinase
myosin light chain kinase 2
phosphodiesterase 1A
phosphodiesterase 1B
phosphodiesterase 1C
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CNGA2 Rn Gating inhibitor Antagonist 7.7 – 8.5 pIC50 - 2,6
⤷ pIC50 7.7 – 8.5 [2,6]
Voltage: -60.0 mV
Kv10.1 Rn Channel blocker - 7.2 pIC50 - 8
⤷ pIC50 7.2 [8]
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphodiesterase 1A Ligand is endogenous in the given species Hs Activator Activation - - -
⤷
phosphodiesterase 1B Ligand is endogenous in the given species Hs Activator Activation - - -
⤷
phosphodiesterase 1C Ligand is endogenous in the given species Hs Activator Activation - - -
⤷
myosin light chain kinase Ligand is endogenous in the given species Hs Activator Activation - - - 4
⤷ [4]
myosin light chain kinase 2 Ligand is endogenous in the given species Hs Activator Activation - - - 4
⤷ [4]
Calmodulin-dependent kinase II Ligand is endogenous in the given species Hs Activator Activation - - -
⤷
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Endogenous activators at adenylyl cyclase 3 calmodulin (CALM2, CALM3, CALM1, P62158), PKC-evoked phosphorylation 3,5
Endogenous activators at adenylyl cyclase 8 calmodulin (CALM2, CALM3, CALM1, P62158) 1
Endogenous activators at adenylyl cyclase 1 calmodulin (CALM2, CALM3, CALM1, P62158), PKC-evoked phosphorylation 5,9
Targets where the ligand is described in the comment field
Target Comment
G protein-coupled receptor kinase 4 Inhibited by Ca2+/calmodulin (CALM2, CALM3, CALM1, P62158) [7]
Ligand mentioned in the following text fields
Adenylyl cyclases (ACs) overview
IP3 receptors overview
Inositol 1,4,5-trisphosphate 3-kinases overview
Nitric oxide synthases overview