Synonyms: Ca2+/calmodulin | Ca2+/CaM | calcium-calmodulin | CaM
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Consists of endogenous peptide calmodulin in complex with up to 4 calcium ions. The name 'calmodulin' is an abbreviation of 'calcium-modulated protein'.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Natural/Endogenous Targets | |||||||
|
Selectivity at ion channels | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Selectivity at enzymes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Endogenous activators at adenylyl cyclase 3 | calmodulin (CALM2, CALM3, CALM1, P62158), PKC-evoked phosphorylation | 3,5 |
Endogenous activators at adenylyl cyclase 8 | calmodulin (CALM2, CALM3, CALM1, P62158) | 1 |
Endogenous activators at adenylyl cyclase 1 | calmodulin (CALM2, CALM3, CALM1, P62158), PKC-evoked phosphorylation | 5,9 |
Targets where the ligand is described in the comment field | |
Target | Comment |
G protein-coupled receptor kinase 4 | Inhibited by Ca2+/calmodulin (CALM2, CALM3, CALM1, P62158) [7] |
Ligand mentioned in the following text fields |
Adenylyl cyclases (ACs) overview |
IP3 receptors overview |
Inositol 1,4,5-trisphosphate 3-kinases overview |
Nitric oxide synthases overview |