calmodulin   Click here for help

GtoPdb Ligand ID: 2351

Synonyms: Ca2+/calmodulin | Ca2+/CaM | calcium-calmodulin | CaM
Comment: Consists of endogenous peptide calmodulin in complex with up to 4 calcium ions. The name 'calmodulin' is an abbreviation of 'calcium-modulated protein'.
Species: Human
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Natural/Endogenous Targets
Target
Calmodulin-dependent kinase II
myosin light chain kinase
myosin light chain kinase 2
phosphodiesterase 1A
phosphodiesterase 1B
phosphodiesterase 1C
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CNGA2 Rn Gating inhibitor Antagonist 7.7 – 8.5 pIC50 - 2,6
pIC50 7.7 – 8.5 [2,6]
Voltage: -60.0 mV
Kv10.1 Rn Channel blocker - 7.2 pIC50 - 8
pIC50 7.2 [8]
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
phosphodiesterase 1A Ligand is endogenous in the given species Hs Activator Activation - - -
phosphodiesterase 1B Ligand is endogenous in the given species Hs Activator Activation - - -
phosphodiesterase 1C Ligand is endogenous in the given species Hs Activator Activation - - -
myosin light chain kinase Ligand is endogenous in the given species Hs Activator Activation - - - 4
[4]
myosin light chain kinase 2 Ligand is endogenous in the given species Hs Activator Activation - - - 4
[4]
Calmodulin-dependent kinase II Ligand is endogenous in the given species Hs Activator Activation - - -
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields