RS 67333   Click here for help

GtoPdb Ligand ID: 237

Synonyms: RS-67333 | RS67, 333 [1] | RS67333
Compound class: Synthetic organic
Comment: RS 67333 is a partial agonist of the 5-HT4 receptor [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 55.56
Molecular weight 352.19
XLogP 3.75
No. Lipinski's rules broken 0
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Canonical SMILES CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N
Isomeric SMILES CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N
InChI InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3
1. Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A et al.. (2014)
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.
Proc Natl Acad Sci USA, 111 (36): E3825-30. [PMID:25157130]
2. Mialet J, Berque-Bestel I, Eftekhari P, Gastineau M, Giner M, Dahmoune Y, Donzeau-Gouge P, Hoebeke J, Langlois M, Sicsic S et al.. (2000)
Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.
Br J Pharmacol, 129 (4): 771-81. [PMID:10683202]
3. Mialet J, Berque-Bestel I, Sicsic S, Langlois M, Fischmeister R, Lezoualc'h F. (2000)
Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
Br J Pharmacol, 131 (4): 827-35. [PMID:11030734]