Synonyms: amiloride HCl | Midamor®
amiloride is an approved drug (FDA (1981))
Compound class:
Synthetic organic
Comment: Amiloride is a loop diuretic drug.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: amiloride |
|
References |
1. Arun T, Tomassini V, Sbardella E, de Ruiter MB, Matthews L, Leite MI, Gelineau-Morel R, Cavey A, Vergo S, Craner M et al.. (2013)
Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride. Brain, 136 (Pt 1): 106-15. [PMID:23365093] |
2. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y. (2001)
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res, 88 (3): 325-32. [PMID:11179201] |
3. Killestein J, Kalkers NF, Polman CH. (2005)
Glutamate inhibition in MS: the neuroprotective properties of riluzole. J Neurol Sci, 233 (1-2): 113-5. [PMID:15949499] |
4. Masereel B, Pochet L, Laeckmann D. (2003)
An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem, 38 (6): 547-54. [PMID:12832126] |
5. Mostert J, Heersema T, Mahajan M, Van Der Grond J, Van Buchem MA, De Keyser J. (2013)
The effect of fluoxetine on progression in progressive multiple sclerosis: a double-blind, randomized, placebo-controlled trial. ISRN Neurol, 2013: 370943. [PMID:23984093] |
6. Mostert JP, Koch MW, Heerings M, Heersema DJ, De Keyser J. (2008)
Therapeutic potential of fluoxetine in neurological disorders. CNS Neurosci Ther, 14 (2): 153-64. [PMID:18482027] |
7. Nagata K, Duggan A, Kumar G, García-Añoveros J. (2005)
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci, 25 (16): 4052-61. [PMID:15843607] |
8. Sieghart W, Savić MM. (2018)
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans. Pharmacol Rev, 70 (4): 836-878. [PMID:30275042] |
9. Waldmann R, Bassilana F, de Weille J, Champigny G, Heurteaux C, Lazdunski M. (1997)
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J Biol Chem, 272 (34): 20975-8. [PMID:9261094] |
10. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. (1997)
A proton-gated cation channel involved in acid-sensing. Nature, 386 (6621): 173-7. [PMID:9062189] |
11. Waldmann R, Champigny G, Voilley N, Lauritzen I, Lazdunski M. (1996)
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J Biol Chem, 271 (18): 10433-6. [PMID:8631835] |