flufenamic acid

Ligand id: 2447

Name: flufenamic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 49.33
Molecular weight 281.07
XLogP 4.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J. (1999)
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.
Nature, 401 (6751): 383-6. [PMID:10517637]
2. Dai L, Garg V, Sanguinetti MC. (2010)
Activation of Slo2.1 channels by niflumic acid.
J. Gen. Physiol., 135 (3): 275-95. [PMID:20176855]
3. Garg P, Sanguinetti MC. (2012)
Structure-activity relationship of fenamates as Slo2.1 channel activators.
Mol. Pharmacol., 82 (5): 795-802. [PMID:22851714]
4. Hill K, Benham CD, McNulty S, Randall AD. (2004)
Flufenamic acid is a pH-dependent antagonist of TRPM2 channels.
Neuropharmacology, 47 (3): 450-60. [PMID:15275834]
5. Hu H, Tian J, Zhu Y, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX. (2010)
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Pflugers Arch., 459 (4): 579-92. [PMID:19888597]
6. Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S. (1998)
Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
J. Biochem., 124 (5): 940-6. [PMID:9792917]
7. Skarydová L, Zivná L, Xiong G, Maser E, Wsól V. (2009)
AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids.
Chem. Biol. Interact., 178 (1-3): 138-44. [PMID:19007764]
8. Togashi K, Inada H, Tominaga M. (2008)
Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).
Br. J. Pharmacol., 153 (6): 1324-30. [PMID:18204483]
9. Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B. (2005)
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice.
Cell Calcium, 37 (3): 267-78. [PMID:15670874]