nifedipine

Ligand id: 2514

Name: nifedipine

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 107.77
Molecular weight 346.12
XLogP 3.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Proc. Natl. Acad. Sci. U.S.A., 95 (21): 12208-13. [PMID:9770465]
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Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol. Pharmacol., 45 (6): 1227-34. [PMID:7517498]
3. Guengerich FP, Martin MV, Beaune PH, Kremers P, Wolff T, Waxman DJ. (1986)
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
J. Biol. Chem., 261 (11): 5051-60. [PMID:3514607]
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Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
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5. Lamb GD, Walsh T. (1987)
Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscles of rat and rabbit.
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The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution.
J. Neurosci., 24 (7): 1707-18. [PMID:14973233]
7. Pignier C, Potreau D. (2000)
Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes.
Am. J. Physiol. Heart Circ. Physiol., 279 (5): H2259-68. [PMID:11045961]
8. Pérez-Vizcaíno F, Tamargo J, Hof RP, Rüegg UT. (1993)
Vascular selectivity of seven prototype calcium antagonists: a study at the single cell level.
J. Cardiovasc. Pharmacol., 22 (5): 768-75. [PMID:7506331]
9. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J. (2009)
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Mol. Pharmacol., 75 (2): 407-14. [PMID:19029287]