Ligand id: 2522

Name: mibefradil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 67.45
Molecular weight 495.29
XLogP 5.1
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Jiménez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J. (2000)
Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.
Neuropharmacology, 39 (1): 1-10. [PMID:10665814]
2. Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA. (2000)
Mibefradil block of cloned T-type calcium channels.
J. Pharmacol. Exp. Ther., 295 (1): 302-8. [PMID:10991994]
3. Strünker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB. (2011)
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.
Nature, 471 (7338): 382-6. [PMID:21412338]