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Synonyms: Posicor® | Ro-405967-001
mibefradil is an approved drug (FDA (1997))
Compound class: Synthetic organic
Comment: Marketed formulations contained mibefradil dihydrochloride (PubChem CID 60662).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Jiménez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J. (2000)
Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.
Neuropharmacology, 39 (1): 1-10. [PMID:10665814]
2. Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA. (2000)
Mibefradil block of cloned T-type calcium channels.
J Pharmacol Exp Ther, 295 (1): 302-8. [PMID:10991994]
3. Strünker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB. (2011)
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.
Nature, 471 (7338): 382-6. [PMID:21412338]