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Compound class: Natural product or derivative
Comment: This compound is also represented on ChEMBL by the entry CHEMBL2103747 which has slightly diffferent stereochemistry than the structure shown here.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Catterall WA, Morrow CS, Daly JW, Brown GB. (1981)
Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles.
J. Biol. Chem., 256 (17): 8922-7. [PMID:6114956]
2. Nilius B, Boldt W, Benndorf K. (1986)
Properties of aconitine-modified sodium channels in single cells of mouse ventricular myocardium.
Gen. Physiol. Biophys., 5 (5): 473-84. [PMID:2433183]
3. Wright SN. (2002)
Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions.
J. Physiol. (Lond.), 538 (Pt 3): 759-71. [PMID:11826163]