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Synonyms: [3H]5-carboxamidotryptamine  | tritiated 5-carbamidotryptamine
Compound class: Synthetic organic
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Grailhe R, Grabtree GW, Hen R. (2001)
Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution.
Eur J Pharmacol, 418 (3): 157-67. [PMID:11343685]
2. Thomas DR, Atkinson PJ, Ho M, Bromidge SM, Lovell PJ, Villani AJ, Hagan JJ, Middlemiss DN, Price GW. (2000)
[(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.
Br J Pharmacol, 130 (2): 409-17. [PMID:10807680]
3. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998)
Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation.
Ann N Y Acad Sci, 861: 85-90. [PMID:9928243]
4. Xie Z, Lee SP, O'Dowd BF, George SR. (1999)
Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.
FEBS Lett, 456 (1): 63-7. [PMID:10452531]