[3H]5-CT   Click here for help

GtoPdb Ligand ID: 262

Synonyms: [3H]5-carboxamidotryptamine [4] | tritiated 5-carbamidotryptamine
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 84.9
Molecular weight 203.11
XLogP 0.3
No. Lipinski's rules broken 0
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Canonical SMILES NCCc1c[nH]c2c1cc(cc2)C(=O)N
Isomeric SMILES NC(=O)c1ccc2c(c1)c(c[nH]2)C(C(N)([3H])[3H])([3H])[3H]
InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)/i3T2,4T2
1. Grailhe R, Grabtree GW, Hen R. (2001)
Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution.
Eur J Pharmacol, 418 (3): 157-67. [PMID:11343685]
2. Thomas DR, Atkinson PJ, Ho M, Bromidge SM, Lovell PJ, Villani AJ, Hagan JJ, Middlemiss DN, Price GW. (2000)
[(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.
Br J Pharmacol, 130 (2): 409-17. [PMID:10807680]
3. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998)
Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation.
Ann N Y Acad Sci, 861: 85-90. [PMID:9928243]
4. Xie Z, Lee SP, O'Dowd BF, George SR. (1999)
Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.
FEBS Lett, 456 (1): 63-7. [PMID:10452531]