Compound class:
Natural product
Comment: Saxitoxin is a potent paralytic neurotoxin saxitoxin that is produced by water-dwelling prokaryotic cyanobacteria and eukaryotic dinoflagellates [3]. Mechanistically it is a voltage-gated sodium (NaV) ion channel blocker.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Bricelj VM, Connell L, Konoki K, Macquarrie SP, Scheuer T, Catterall WA, Trainer VL. (2005)
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature, 434 (7034): 763-7. [PMID:15815630] |
2. Cribbs LL, Satin J, Fozzard HA, Rogart RB. (1990)
Functional expression of the rat heart I Na+ channel isoform. Demonstration of properties characteristic of native cardiac Na+ channels. FEBS Lett, 275 (1-2): 195-200. [PMID:2175715] |
3. Cusick KD, Sayler GS. (2013)
An overview on the marine neurotoxin, saxitoxin: genetics, molecular targets, methods of detection and ecological functions. Mar Drugs, 11 (4): 991-1018. [PMID:23535394] |
4. Penzotti JL, Lipkind G, Fozzard HA, Dudley Jr SC. (2001)
Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J, 80 (2): 698-706. [PMID:11159437] |
5. Walker JR, Novick PA, Parsons WH, McGregor M, Zablocki J, Pande VS, Du Bois J. (2012)
Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]. Proc Natl Acad Sci USA, 109 (44): 18102-7. [PMID:23077250] |
6. Zeng D, Kyle JW, Martin RL, Ambler KS, Hanck DA. (1996)
Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8. Am J Physiol, 270 (5 Pt 1): C1522-31. [PMID:8967455] |