- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: Eltroxin® | L-thyroxine | levothyroxine | levothyroxine sodium
T4 is an approved drug (FDA (2000))
Compound class: Metabolite or derivative
Comment: Thyroid hormone receptor agonist
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: t4
1. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH. (2006)
Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism.
Mol Endocrinol, 20 (11): 2761-72. [PMID:16887882]
2. Schueler PA, Schwartz HL, Strait KA, Mariash CN, Oppenheimer JH. (1990)
Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3.
Mol Endocrinol, 4 (2): 227-34. [PMID:2158622]