Compound class:
Metabolite or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. (1995)
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell, 83 (5): 813-9. [PMID:8521498] |
2. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM. (1997)
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA, 94 (9): 4318-23. [PMID:9113987] |
3. Nichols JS, Parks DJ, Consler TG, Blanchard SG. (1998)
Development of a scintillation proximity assay for peroxisome proliferator-activated receptor gamma ligand binding domain. Anal Biochem, 257 (2): 112-9. [PMID:9514791] |
4. Nosjean O, Boutin JA. (2002)
Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?. Cell Signal, 14 (7): 573-83. [PMID:11955950] |
5. Soares AF, Nosjean O, Cozzone D, D'Orazio D, Becchi M, Guichardant M, Ferry G, Boutin JA, Lagarde M, Géloën A. (2005)
Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. Biochem Biophys Res Commun, 337 (2): 521-5. [PMID:16198309] |