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vitamin D3 is an approved drug
Compound class: Metabolite or derivative
Comment: Vitamin D3 is one of five forms of vitamin D. It is an inactive steroid molecule with one ring open (secosteroid). Vitamin D3 is converted to bioactive calcitriol by successive hydroxylations in the liver and kidney.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW. (2003)
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
J. Biol. Chem., 278 (39): 38084-93. [PMID:12867411]
2. Otte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, Cheruvallath Z, Jackson D, Casari G, Koegl M, Pääbo S, Mous J, Kremoser C, Deuschle U. (2003)
Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.
Mol. Cell. Biol., 23 (3): 864-72. [PMID:12529392]