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Synonyms: C473027 | GW 3965 | GW-3965
Compound class: Synthetic organic
Comment: GW3965 is a synthetic agonist of the liver X receptors (LXRs) α and β.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM. (2002)
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
J Med Chem, 45 (10): 1963-6. [PMID:11985463]
2. Herold M, Breuer J, Hucke S, Knolle P, Schwab N, Wiendl H, Klotz L. (2017)
Liver X receptor activation promotes differentiation of regulatory T cells.
PLoS ONE, 12 (9): e0184985. [PMID:28926619]