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Synonyms: (-)-deoxyschisandrin | (-)-dimethylgomisin J | deoxyschizandrin | schizandrin-A
Compound class:
Natural product
Comment: Schisandrin A is a lignan derived from the fruiting bodies of the Schisandra chinensis vine.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Li WL, Xin HW, Su MW, Xiong L. (2010)
Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity. Methods Find Exp Clin Pharmacol, 32 (3): 163-9. [PMID:20448858] |
2. Mu Y, Zhang J, Zhang S, Zhou HH, Toma D, Ren S, Huang L, Yaramus M, Baum A, Venkataramanan R, Xie W. (2006)
Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther, 316 (3): 1369-77. [PMID:16267138] |
3. Qin XL, Chen X, Wang Y, Xue XP, Wang Y, Li JL, Wang XD, Zhong GP, Wang CX, Yang H et al.. (2014)
In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. Drug Metab Dispos, 42 (1): 193-9. [PMID:24195812] |
4. Wu J, Cao Y, Zhang Y, Liu Y, Hong JY, Zhu L, Ge G, Yang L. (2014)
Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A. Drug Metab Dispos, 42 (1): 94-104. [PMID:24131672] |