Ligand id: 3250

Name: [125I]GTI    

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 6
Rotatable bonds 13
Topological polar surface area 172.56
Molecular weight 579.1
XLogP 0.96
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Boulenguez P, Segu L, Chauveau J, Morel A, Lanoir J, Delaage M. (1992)
Biochemical and pharmacological characterization of serotonin-O-carboxymethylglycyl[125I]iodotyrosinamide, a new radioiodinated probe for 5-HT1B and 5-HT1D binding sites.
J. Neurochem., 58 (3): 951-9. [PMID:1738002]
2. Bruinvels AT, Palacios JM, Hoyer D. (1993)
Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain.
Naunyn Schmiedebergs Arch. Pharmacol., 347 (6): 569-82. [PMID:8361548]
3. Palacios JM, Waeber C, Bruinvels AT, Hoyer D. (1992)
Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand.
Brain Res. Mol. Brain Res., 13 (1-2): 175-8. [PMID:1315914]