pirenzepine   Click here for help

GtoPdb Ligand ID: 328

Approved drug
pirenzepine is an approved drug
Compound class: Synthetic organic
Comment: Pirenzepine muscarinic acetylcholine receptor antagonist, selective for the M1 receptor subtype.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: pirenzepine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 74.23
Molecular weight 351.17
XLogP 1.32
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2
Isomeric SMILES CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2
InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
InChI Key RMHMFHUVIITRHF-UHFFFAOYSA-N
References
1. Buckley NJ, Bonner TI, Buckley CM, Brann MR. (1989)
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
Mol Pharmacol, 35 (4): 469-76. [PMID:2704370]
2. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. (2018)
Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.
Invest Ophthalmol Vis Sci, 59 (7): 2778-2791. [PMID:29860464]
3. Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, Ott SH, Elson AE, Choi HJ, Shaw H, Egan JM et al.. (2008)
Bitter taste receptors influence glucose homeostasis.
PLoS One, 3 (12): e3974. [PMID:19092995]
4. Dörje F, Wess J, Lambrecht G, Tacke R, Mutschler E, Brann MR. (1991)
Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
J Pharmacol Exp Ther, 256 (2): 727-33. [PMID:1994002]
5. Hegde SS, Choppin A, Bonhaus D, Briaud S, Loeb M, Moy TM, Loury D, Eglen RM. (1997)
Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo.
Br J Pharmacol, 120 (8): 1409-18. [PMID:9113359]
6. Huang F, Buchwald P, Browne CE, Farag HH, Wu WM, Ji F, Hochhaus G, Bodor N. (2001)
Receptor binding studies of soft anticholinergic agents.
AAPS PharmSci, 3 (4): E30. [PMID:12049493]
7. Jolkkonen M, van Giersbergen PL, Hellman U, Wernstedt C, Karlsson E. (1994)
A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors.
FEBS Lett, 352 (1): 91-4. [PMID:7925952]
8. Kashihara K, Varga EV, Waite SL, Roeske WR, Yamamura HI. (1992)
Cloning of the rat M3, M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chain reaction (PCR) and the pharmacological characterization of the expressed genes.
Life Sci, 51 (12): 955-71. [PMID:1325587]
9. Kovacs I, Yamamura HI, Waite SL, Varga EV, Roeske WR. (1998)
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
J Pharmacol Exp Ther, 284 (2): 500-7. [PMID:9454790]
10. Nelson CP, Nahorski SR, Challiss RA. (2006)
Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
J Pharmacol Exp Ther, 316 (1): 279-88. [PMID:16188951]
11. Stein R, Pinkas-Kramarski R, Sokolovsky M. (1988)
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
EMBO J, 7 (10): 3031-5. [PMID:2846274]
12. Wess J, Lambrecht G, Mutschler E, Brann MR, Dörje F. (1991)
Selectivity profile of the novel muscarinic antagonist UH-AH 37 determined by the use of cloned receptors and isolated tissue preparations.
Br J Pharmacol, 102 (1): 246-50. [PMID:2043926]