gastric inhibitory polypeptide   Click here for help

GtoPdb Ligand ID: 3542

Abbreviated name: GIP
Synonyms: GIP(1-42)
Comment: Human GIP differs from mouse GIP at residues 18 (Histidine), 30 (Lysine) and 34 (Asparagine) and from rat at residues 18 and 40.
Species: Human
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1. Gelling RW, Coy DH, Pederson RA, Wheeler MB, Hinke S, Kwan T, McIntosh CH. (1997)
GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro.
Regul Pept, 69 (3): 151-4. [PMID:9226399]
2. Hansen LS, Sparre-Ulrich AH, Christensen M, Knop FK, Hartmann B, Holst JJ, Rosenkilde MM. (2016)
N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor.
Br J Pharmacol, 173 (5): 826-38. [PMID:26572091]
3. Volz A, Göke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, Göke B. (1995)
Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.
FEBS Lett, 373 (1): 23-9. [PMID:7589426]