gastric inhibitory polypeptide   Click here for help

GtoPdb Ligand ID: 3542

Abbreviated name: GIP
Synonyms: GIP(1-42)
Compound class: Endogenous peptide in human, mouse or rat
Comment: Human GIP differs from mouse GIP at residues 18 (Histidine), 30 (Lysine) and 34 (Asparagine) and from rat at residues 18 and 40.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: gastric inhibitory peptide

Natural/Endogenous Targets
Target
GIP receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GIP receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.7 pKd - 3
⤷ pKd 8.7 [3]
GIP receptor Hs Agonist Agonist 9.1 pKi - 2
⤷ pKi 9.1 (Ki 7.5x10-10 M) [2]
GIP receptor Rn Agonist Full agonist 8.6 pIC50 - 1
⤷ pIC50 8.6 [1]
Ligand mentioned in the following text fields
Glucagon receptor family overview