R-spondin-1   Click here for help

GtoPdb Ligand ID: 3697

Synonyms: hRspo1 | roof plate-specific spondin-1
Species: Human
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1. Carmon KS, Gong X, Lin Q, Thomas A, Liu Q. (2011)
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Proc Natl Acad Sci USA, 108 (28): 11452-7. [PMID:21693646]
2. de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M et al.. (2011)
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature, 476 (7360): 293-7. [PMID:21727895]