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Synonyms: 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid | ABC inhibitor 2 
Compound class: Synthetic organic
Comment: This compound inhibits ATP-binding cassette transporter 1 (ABCA1) .
There is some ambiguity as to the exact structure of this compund, with both the (E) and (Z) forms reported in the literature and on supplier websites. We show the (E) bond. The (Z) is shown in PubChem CID 9548709.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Baldwin AG, Brough D, Freeman S. (2016)
Inhibiting the Inflammasome: A Chemical Perspective.
J Med Chem, 59 (5): 1691-710. [PMID:26422006]
2. Becq F, Hamon Y, Bajetto A, Gola M, Verrier B, Chimini G. (1997)
ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes.
J Biol Chem, 272 (5): 2695-9. [PMID:9006906]
3. Hamon Y, Luciani MF, Becq F, Verrier B, Rubartelli A, Chimini G. (1997)
Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.
Blood, 90 (8): 2911-5. [PMID:9376570]
4. Schulz P, Werner J, Stauber T, Henriksen K, Fendler K. (2010)
The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect.
PLoS ONE, 5 (9): e12585. [PMID:20830208]