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Compound class: Synthetic organic
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Auchampach JA, Kreckler LM, Wan TC, Maas JE, van der Hoeven D, Gizewski E, Narayanan J, Maas GE. (2009)
Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.
J. Pharmacol. Exp. Ther., 329 (1): 2-13. [PMID:19141710]
2. Fozard JR, Baur F, Wolber C. (2003)
Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog.
Eur. J. Pharmacol., 475 (1-3): 79-84. [PMID:12954362]
3. Ji X, Kim YC, Ahern DG, Linden J, Jacobson KA. (2001)
[3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors.
Biochem. Pharmacol., 61 (6): 657-63. [PMID:11266650]
4. Kim YC, Ji X, Melman N, Linden J, Jacobson KA. (2000)
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.
J. Med. Chem., 43 (6): 1165-72. [PMID:10737749]