Ligand id: 4613

Name: fenfluramine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 12.03
Molecular weight 231.12
XLogP 3.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV. (1997)
Valvular heart disease associated with fenfluramine-phentermine.
N. Engl. J. Med., 337 (9): 581-8. [PMID:9271479]
2. Erickson JD, Schafer MK, Bonner TI, Eiden LE, Weihe E. (1996)
Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
Proc. Natl. Acad. Sci. U.S.A., 93 (10): 5166-71. [PMID:8643547]
3. Mitchell P, Hickie I, Torda T. (1992)
Propofol and ECT.
Br J Psychiatry, 161: 861-2. [PMID:1307869]
4. Vickers SP, Dourish CT, Kennett GA. (2001)
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors.
Neuropharmacology, 41 (2): 200-9. [PMID:11489456]