[14C]histidine   Click here for help

GtoPdb Ligand ID: 4623

Synonyms: [14C]-histidine
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 92
Molecular weight 155.07
XLogP -3.12
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES NC(C(=O)O)Cc1c[nH]cn1
Isomeric SMILES N[14C@H](C(=O)O)Cc1c[nH]cn1
InChI InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1/i5+2
InChI Key HNDVDQJCIGZPNO-YDUYVQCESA-N
References
1. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. (2001)
Cloning of a lymphatic peptide/histidine transporter.
Biochem J, 356 (Pt 1): 53-60. [PMID:11336635]
2. Wang XX, Hu Y, Keep RF, Toyama-Sorimachi N, Smith DE. (2017)
A novel role for PHT1 in the disposition of l-histidine in brain: In vitro slice and in vivo pharmacokinetic studies in wildtype and Pht1 null mice.
Biochem Pharmacol, 124: 94-102. [PMID:27845049]
3. Wang XX, Li YB, Feng MR, Smith DE. (2018)
Semi-Mechanistic Population Pharmacokinetic Modeling of L-Histidine Disposition and Brain Uptake in Wildtype and Pht1 Null Mice.
Pharm Res, 35 (1): 19. [PMID:29305823]
4. Yamashita T, Shimada S, Guo W, Sato K, Kohmura E, Hayakawa T, Takagi T, Tohyama M. (1997)
Cloning and functional expression of a brain peptide/histidine transporter.
J Biol Chem, 272 (15): 10205-11. [PMID:9092568]