phlorizin   Click here for help

GtoPdb Ligand ID: 4757

Comment: Found in the bark of several types of fruit tree. Within the body, phlorizin (which also occurs naturally) is converted into phloretin by hydrolytic enzymes.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 7
Rotatable bonds 7
Topological polar surface area 177.14
Molecular weight 436.14
XLogP 1.1
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES OCC1OC(Oc2cc(O)cc(c2C(=O)CCc2ccc(cc2)O)O)C(C(C1O)O)O
Isomeric SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(c2C(=O)CCc2ccc(cc2)O)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
InChI Key IOUVKUPGCMBWBT-QNDFHXLGSA-N
References
1. Coady MJ, Wallendorff B, Gagnon DG, Lapointe JY. (2002)
Identification of a novel Na+/myo-inositol cotransporter.
J Biol Chem, 277 (38): 35219-24. [PMID:12133831]
2. Horiba N, Masuda S, Takeuchi A, Takeuchi D, Okuda M, Inui K. (2003)
Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney.
J Biol Chem, 278 (17): 14669-76. [PMID:12590146]