amyloid β   Click here for help

GtoPdb Ligand ID: 4865

Synonyms: amyloid β-peptide | beta-amyloid protein
Comment: We give the sequence for the 42 amino acid peptide here, but note that use of the name β-amyloid generally refers to the ensemble of peptides of 40 to 43 residues excised from the precursor APP protein by the combined action of β- and γ-secretases. These peptides may be soluble monomers or oligomers and contribute to the formation of fibrils and plaques that are associated with Alzheimer's disease.

The amino acid sequences of alternative forms are;

So far we have annotated three types of target relationships for β-amyloid:
1) antibodies directed against the peptide forms for depletion
2) aggregation antagonists
3) imaging reagents for detection
Species: Human
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1. Bardroff M, Bohrmann B, Brockhaus M, Huber W, Kretzschmar T, Loetscher H, Löhning C, Nordstedt C, Rothe C. (2010)
variable regions peptides for immunizing against amyloid plaque formation; biodrug for dementia, Alzheimer's disease, neuropathy, Down's syndrome, Creutzfeld Jacob disease, Parkinson's disease, amyotropic lateral sclerosis; neuroprotectants; hemostatic agent.
Patent number: US7794719. Assignee: Hoffmann-La Roche Ag, Morphosys Ag. Priority date: 20/02/2002. Publication date: 14/09/2010.
2. Bussiere T, Weinreb PH, Engber T, Rhodes K, Arndt J, Qian F, Dunstan RW, Patel S. (2014)
Patent number: WO2014089500. Assignee: Biogen Idec International Neuroscience Gmbh. Priority date: 07/12/2012. Publication date: 12/06/2014.
3. Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF. (2009)
Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain.
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4. Dewji NN, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. (2015)
Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce ß-Amyloid in Alzheimer's Disease.
PLoS ONE, 10 (4): e0122451. [PMID:25923432]
5. Garber K. (2012)
Genentech's Alzheimer's antibody trial to study disease prevention.
Nat Biotechnol, 30 (8): 731-2. [PMID:22871696]
6. Holtzman DM, DeMattos R, Bales KR, Paul SM, Tsurushita N, Vasquez M. (2007)
Humanized antibodies that sequester abeta peptide.
Patent number: US7195761. Assignee: Eli Lilly And Company, Washington University. Priority date: 24/02/2002. Publication date: 27/03/2007.
7. Le Y, Gong W, Tiffany HL, Tumanov A, Nedospasov S, Shen W, Dunlop NM, Gao JL, Murphy PM, Oppenheim JJ et al.. (2001)
Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.
J Neurosci, 21 (2): RC123. [PMID:11160457]
8. Miles LA, Crespi GA, Doughty L, Parker MW. (2013)
Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.
Sci Rep, 3: 1302. [PMID:23416764]
9. Pfeifer A, Pihlgren M, Muhs A, Watts R. (2011)
Humanized anti-beta-amyloid antibody.
Patent number: US7892544. Assignee: Ac Immune Sa, Genentech, Inc.. Priority date: 14/07/2006. Publication date: 22/10/2012.
10. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G et al.. (2013)
Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.
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11. Rozema NB, Procissi D, Bertolino N, Viola KL, Nandwana V, Abdul N, Pribus S, Dravid V, Klein WL, Disterhoft JF et al.. (2020)
Aβ oligomer induced cognitive impairment and evaluation of ACU193-MNS-based MRI in rabbit.
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12. Tiffany HL, Lavigne MC, Cui YH, Wang JM, Leto TL, Gao JL, Murphy PM. (2001)
Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.
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¹⁸F-labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques.
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Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA).
J Med Chem, 54 (23): 8085-98. [PMID:22011144]