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Synonyms: amyloid β-peptide | beta-amyloid protein
Compound class:
Endogenous peptide in human, mouse or rat
Comment: We give the sequence for the 42 amino acid peptide here, but note that use of the name β-amyloid generally refers to the ensemble of peptides of 40 to 43 residues excised from the precursor APP protein by the combined action of β- and γ-secretases. These peptides may be soluble monomers or oligomers and contribute to the formation of fibrils and plaques that are associated with Alzheimer's disease.
The amino acid sequences of alternative forms are; 1-40 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV 1-42 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 1-43 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIAT So far we have annotated three types of target relationships for β-amyloid: 1) antibodies directed against the peptide forms for depletion 2) aggregation antagonists 3) imaging reagents for detection
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Peptide Sequence  |
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| DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA | |
| Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala | |
| Selected 3D Structures | ||
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