C-type natriuretic peptide

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Ligands
C-type natriuretic peptide (Human)

GtoPdb Ligand ID: 4896

Abbreviated name: CNP

Synonyms: CNP-22

Compound class: Endogenous peptide in human, mouse or rat

Comment: CNP is a a positive regulator of endochondral bone growth, and prevents dwarfism in mouse models of achondroplasia [2].

Species: Human

View more information in the IUPHAR Pharmacology Education Project: c-type natriuretic peptide

References
1. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]
2. Wendt DJ, Dvorak-Ewell M, Bullens S, Lorget F, Bell SM, Peng J, Castillo S, Aoyagi-Scharber M, O'Neill CA, Krejci P et al.. (2015) Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism. J Pharmacol Exp Ther, 353 (1): 132-49. [PMID:25650377]

References

1. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992)
Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.
Endocrinology, 130 (1): 229-39. [PMID:1309330]

2. Wendt DJ, Dvorak-Ewell M, Bullens S, Lorget F, Bell SM, Peng J, Castillo S, Aoyagi-Scharber M, O'Neill CA, Krejci P et al.. (2015)
Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism.
J Pharmacol Exp Ther, 353 (1): 132-49. [PMID:25650377]