C-type natriuretic peptide   Click here for help

GtoPdb Ligand ID: 4896

Abbreviated name: CNP
Synonyms: CNP-22
Compound class: Endogenous peptide in human, mouse or rat
Comment: CNP is a a positive regulator of endochondral bone growth, and prevents dwarfism in mouse models of achondroplasia [2].
Species: Human
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Natural/Endogenous Targets
Target
Guanylyl cyclase-B
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Guanylyl cyclase-B Ligand is endogenous in the given species Hs Agonist Binding - - - 1
⤷ [1]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order at Guanylyl cyclase-A atrial natriuretic peptide (NPPA, P01160) ≥ brain natriuretic peptide (NPPB, P16860) >> C-type natriuretic peptide (NPPC, P23582) 1
Potency order at Guanylyl cyclase-B C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860) 1
Potency order at natriuretic peptide receptor 3 atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860) 1