Top ▲
Target not currently curated in GtoImmuPdb
Target id: 1749
Nomenclature: natriuretic peptide receptor 3
Abbreviated Name: NPR-C
Family: Transmembrane guanylyl cyclases
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 541 | 5p13.3 | NPR3 | natriuretic peptide receptor 3 | |
| Mouse | 1 | 536 | 15 5.83 cM | Npr3 | natriuretic peptide receptor 3 | |
| Rat | 1 | 535 | 2q16 | Npr3 | natriuretic peptide receptor 3 | |
| Previous and Unofficial Names |
| ANP-C | ANP-CR | ANPR-C | Atrial natriuretic peptide clearence receptor 3 | atrial natriuretic peptide receptor 3 | atrial natriuretic peptide receptor type C | GUCY2B | lgj | longjohn | natriuretic peptide receptor-C | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | Nppc receptor | NPR3 |
| Database Links |
|
| Alphafold | P17342 (Hs), P70180 (Mm), P41740 (Rn) |
| ChEMBL Target | CHEMBL2247 (Hs), CHEMBL4711 (Mm) |
| Ensembl Gene | ENSG00000113389 (Hs), ENSMUSG00000022206 (Mm), ENSRNOG00000019184 (Rn) |
| Entrez Gene | 4883 (Hs), 18162 (Mm), 25339 (Rn) |
| Human Protein Atlas | ENSG00000113389 (Hs) |
| KEGG Gene | hsa:4883 (Hs), mmu:18162 (Mm), rno:25339 (Rn) |
| OMIM | 108962 (Hs) |
| Pharos | P17342 (Hs) |
| UniProtKB | P17342 (Hs), P70180 (Mm), P41740 (Rn) |
| Wikipedia | NPR3 (Hs) |
| Natural/Endogenous Ligands |
| osteocrin {Sp: Human} |
| Potency order (Human) |
| atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860) [5] |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||
1. Edelson JD, Makhlina M, Silvester KR, Vengurlekar SS, Chen X, Zhang J, Koziol-White CJ, Cooper PR, Hallam TJ, Hay DW et al.. (2013) In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther, 26 (2): 229-38. [PMID:23154072]
2. Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A. (2004) Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation, 110 (10): 1231-5. [PMID:15337698]
3. Maack T, Suzuki M, Almeida FA, Nussenzveig D, Scarborough RM, McEnroe GA, Lewicki JA. (1987) Physiological role of silent receptors of atrial natriuretic factor. Science, 238 (4827): 675-8. [PMID:2823385]
4. Moffatt P, Thomas G, Sellin K, Bessette MC, Lafrenière F, Akhouayri O, St-Arnaud R, Lanctôt C. (2007) Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. J Biol Chem, 282 (50): 36454-62. [PMID:17951249]
5. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]
6. Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR, Dantzman CL, Edwards PD, Jacobs RT et al.. (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett, 10 (17): 1949-52. [PMID:10987424]
