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Guanylyl cyclase-B

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Target not currently curated in GtoImmuPdb

Target id: 1748

Nomenclature: Guanylyl cyclase-B

Abbreviated Name: GC-B

Family: Transmembrane guanylyl cyclases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1047 9p13.3 NPR2 natriuretic peptide receptor 2
Mouse 1 1047 4 23.05 cM Npr2 natriuretic peptide receptor 2
Rat 1 1047 5q22 Npr2 natriuretic peptide receptor 2
Previous and Unofficial Names Click here for help
ANPB receptor | natriuretic peptide receptor 2 | ANP-B | ANPR-B | atrial natriuretic peptide receptor 2 | atrial natriuretic peptide receptor B | guanylate cyclase B | atrionatriuretic peptide receptor B | natriuretic peptide receptor-B
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands Click here for help
C-type natriuretic peptide {Sp: Human}
Potency order (Human)
C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860)  [6]

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cenderitide Peptide Click here for species-specific activity table Hs Agonist - - 4
vosoritide Peptide Approved drug Hs Agonist - - 3
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
peptide P19 [PMID: 15652659] Peptide Hs Antagonist 7.8 pKd 2
pKd 7.8 [2]
HS-142-1 Small molecule or natural product Click here for species-specific activity table Hs Antagonist - - 5
compound C10 [PMID: 24297249] Small molecule or natural product Hs Antagonist - - 1
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Bach T, Bergholtz S, Riise J, Qvigstad E, Skomedal T, Osnes JB, Levy FO. (2014) Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure. Naunyn Schmiedebergs Arch Pharmacol, 387 (1): 5-14. [PMID:24297249]

2. Deschênes J, Duperé C, McNicoll N, L'Heureux N, Auger F, Fournier A, De Léan A. (2005) Development of a selective peptide antagonist for the human natriuretic peptide receptor-B. Peptides, 26 (3): 517-24. [PMID:15652659]

3. Lorget F, Kaci N, Peng J, Benoist-Lasselin C, Mugniery E, Oppeneer T, Wendt DJ, Bell SM, Bullens S, Bunting S et al.. (2012) Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am J Hum Genet, 91 (6): 1108-14. [PMID:23200862]

4. Martin FL, Sangaralingham SJ, Huntley BK, McKie PM, Ichiki T, Chen HH, Korinek J, Harders GE, Burnett Jr JC. (2012) CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart. PLoS ONE, 7 (12): e52422. [PMID:23272242]

5. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y. (1991) Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem Biophys Res Commun, 176 (3): 949-57. [PMID:1674870]

6. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]


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