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Target not currently curated in GtoImmuPdb
Target id: 1748
Nomenclature: Guanylyl cyclase-B
Abbreviated Name: GC-B
Family: Transmembrane guanylyl cyclases
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 1047 | 9p13.3 | NPR2 | natriuretic peptide receptor 2 | |
| Mouse | 1 | 1047 | 4 23.05 cM | Npr2 | natriuretic peptide receptor 2 | |
| Rat | 1 | 1047 | 5q22 | Npr2 | natriuretic peptide receptor 2 | |
| Previous and Unofficial Names |
| ANPB receptor | natriuretic peptide receptor 2 | ANP-B | ANPR-B | atrial natriuretic peptide receptor 2 | atrial natriuretic peptide receptor B | guanylate cyclase B | atrionatriuretic peptide receptor B | natriuretic peptide receptor-B |
| Database Links |
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| Alphafold | P20594 (Hs), Q6VVW5 (Mm), P16067 (Rn) |
| CATH/Gene3D | 3.30.70.1230 |
| ChEMBL Target | CHEMBL1795 (Hs) |
| DrugBank Target | P20594 (Hs) |
| Ensembl Gene | ENSG00000159899 (Hs), ENSMUSG00000028469 (Mm), ENSRNOG00000015991 (Rn) |
| Entrez Gene | 4882 (Hs), 230103 (Mm), 116564 (Rn) |
| Human Protein Atlas | ENSG00000159899 (Hs) |
| KEGG Gene | hsa:4882 (Hs), mmu:230103 (Mm), rno:116564 (Rn) |
| OMIM | 108961 (Hs) |
| Pharos | P20594 (Hs) |
| UniProtKB | P20594 (Hs), Q6VVW5 (Mm), P16067 (Rn) |
| Wikipedia | NPR2 (Hs) |
| Natural/Endogenous Ligands |
| C-type natriuretic peptide {Sp: Human} |
| Potency order (Human) |
| C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860) [8] |
Download all structure-activity data for this target as a CSV file 
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1. Bach T, Bergholtz S, Riise J, Qvigstad E, Skomedal T, Osnes JB, Levy FO. (2014) Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure. Naunyn Schmiedebergs Arch Pharmacol, 387 (1): 5-14. [PMID:24297249]
2. Breinholt VM, Rasmussen CE, Mygind PH, Kjelgaard-Hansen M, Faltinger F, Bernhard A, Zettler J, Hersel U. (2019) TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3-Related Skeletal Dysplasias. J Pharmacol Exp Ther, 370 (3): 459-471. [PMID:31235532]
3. Deschênes J, Duperé C, McNicoll N, L'Heureux N, Auger F, Fournier A, De Léan A. (2005) Development of a selective peptide antagonist for the human natriuretic peptide receptor-B. Peptides, 26 (3): 517-24. [PMID:15652659]
4. Lorget F, Kaci N, Peng J, Benoist-Lasselin C, Mugniery E, Oppeneer T, Wendt DJ, Bell SM, Bullens S, Bunting S et al.. (2012) Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am J Hum Genet, 91 (6): 1108-14. [PMID:23200862]
5. Ma X, Peddibhotla S, Zheng Y, Pan S, Mehta A, Moroni DG, Chen QY, Ma X, Burnett Jr JC, Malany S et al.. (2024) Discovery of small molecule guanylyl cyclase B receptor positive allosteric modulators. PNAS Nexus, 3 (6): pgae225. [PMID:38894878]
6. Martin FL, Sangaralingham SJ, Huntley BK, McKie PM, Ichiki T, Chen HH, Korinek J, Harders GE, Burnett Jr JC. (2012) CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart. PLoS ONE, 7 (12): e52422. [PMID:23272242]
7. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y. (1991) Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem Biophys Res Commun, 176 (3): 949-57. [PMID:1674870]
8. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]
