IL-10   Click here for help

GtoPdb Ligand ID: 4975

Synonyms: interleukin-10
Immunopharmacology Ligand
Comment: Biologically active IL-10 is a homodimer. It is an anti-inflammatory cytokine.
Species: Human
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1. Fillatreau S, Gray D, Anderton SM. (2008)
Not always the bad guys: B cells as regulators of autoimmune pathology.
Nat Rev Immunol, 8 (5): 391-7. [PMID:18437156]
2. Mosser DM, Zhang X. (2008)
Interleukin-10: new perspectives on an old cytokine.
Immunol Rev, 226: 205-18. [PMID:19161426]
3. Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Rojo B, Autio KA, Wong DJ, Patel MR et al.. (2018)
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients.
Cancer Cell, 34 (5): 775-791.e3. [PMID:30423297]
4. Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, Falchook GS, Pant S, Whiteside M, Rasco DR et al.. (2016)
Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors.
J Clin Oncol, 34 (29): 3562-3569. [PMID:27528724]
5. O'Garra A, Vieira P. (2007)
T(H)1 cells control themselves by producing interleukin-10.
Nat Rev Immunol, 7 (6): 425-8. [PMID:17525751]
6. Ryan JJ, Kashyap M, Bailey D, Kennedy S, Speiran K, Brenzovich J, Barnstein B, Oskeritzian C, Gomez G. (2007)
Mast cell homeostasis: a fundamental aspect of allergic disease.
Crit Rev Immunol, 27 (1): 15-32. [PMID:17430094]
7. Schwager K, Kaspar M, Bootz F, Marcolongo R, Paresce E, Neri D, Trachsel E. (2009)
Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis.
Arthritis Res Ther, 11 (5): R142. [PMID:19781067]