IL-10   Click here for help

GtoPdb Ligand ID: 4975

Synonyms: interleukin-10
Immunopharmacology Ligand
Comment: Biologically active IL-10 is a homodimer. It is an anti-inflammatory cytokine.
Species: Human
Click here for help
References
1. Fillatreau S, Gray D, Anderton SM. (2008)
Not always the bad guys: B cells as regulators of autoimmune pathology.
Nat. Rev. Immunol., 8 (5): 391-7. [PMID:18437156]
2. Mosser DM, Zhang X. (2008)
Interleukin-10: new perspectives on an old cytokine.
Immunol. Rev., 226: 205-18. [PMID:19161426]
3. Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Rojo B, Autio KA, Wong DJ, Patel MR et al.. (2018)
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients.
Cancer Cell, 34 (5): 775-791.e3. [PMID:30423297]
4. Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, Falchook GS, Pant S, Whiteside M, Rasco DR et al.. (2016)
Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors.
J. Clin. Oncol., 34 (29): 3562-3569. [PMID:27528724]
5. O'Garra A, Vieira P. (2007)
T(H)1 cells control themselves by producing interleukin-10.
Nat. Rev. Immunol., 7 (6): 425-8. [PMID:17525751]
6. Ryan JJ, Kashyap M, Bailey D, Kennedy S, Speiran K, Brenzovich J, Barnstein B, Oskeritzian C, Gomez G. (2007)
Mast cell homeostasis: a fundamental aspect of allergic disease.
Crit. Rev. Immunol., 27 (1): 15-32. [PMID:17430094]
7. Schwager K, Kaspar M, Bootz F, Marcolongo R, Paresce E, Neri D, Trachsel E. (2009)
Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis.
Arthritis Res. Ther., 11 (5): R142. [PMID:19781067]