phentolamine   Click here for help

GtoPdb Ligand ID: 502

Synonyms: dibasin | fentolamin | Regitine® | Rogitine®
Approved drug
phentolamine is an approved drug (FDA (1952))
Compound class: Synthetic organic
Comment: Phentolamine is a non-selective alpha-adrenergic receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 47.86
Molecular weight 281.15
XLogP 3.26
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1
Isomeric SMILES Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1
InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
1. Bylund DB, Blaxall HS, Iversen LJ, Caron MG, Lefkowitz RJ, Lomasney JW. (1992)
Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.
Mol Pharmacol, 42: 1-5. [PMID:1353247]
2. Devedjian JC, Esclapez F, Denis-Pouxviel C, Paris H. (1994)
Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs.
Eur J Pharmacol, 252 (1): 43-9. [PMID:7908642]
3. Shibata K, Foglar R, Horie K, Obika K, Sakamoto A, Ogawa S, Tsujimoto G. (1995)
KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
Mol Pharmacol, 48 (2): 250-8. [PMID:7651358]
4. Waugh DJ, Gaivin RJ, Zuscik MJ, Gonzalez-Cabrera P, Ross SA, Yun J, Perez DM. (2001)
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists.
J Biol Chem, 276 (27): 25366-71. [PMID:11331292]