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Abbreviated name: ρ-TIA
Synonyms: ρ-TIA conotoxin | 19-amino acid conopeptide | rho-conotoxin TIA
Compound class: Peptide or derivative
Comment: From Conus tulipa (Fish-hunting cone snail or Tulip cone)
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Chen Z, Rogge G, Hague C, Alewood D, Colless B, Lewis RJ, Minneman KP. (2004)
Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA.
J. Biol. Chem., 279 (34): 35326-33. [PMID:15194691]
2. Lima V, Mueller A, Kamikihara SY, Raymundi V, Alewood D, Lewis RJ, Chen Z, Minneman KP, Pupo AS. (2005)
Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta.
Eur. J. Pharmacol., 508 (1-3): 183-92. [PMID:15680270]
3. Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF et al.. (2003)
Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.
J. Biol. Chem., 278 (36): 34451-7. [PMID:12824165]