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Synonyms: D5v8 | Herceptin® | R-597
trastuzumab is an approved drug (FDA (1998), EMA (2000))
Compound class: Antibody
Comment: Trastuzumab is a humanized IgG1κ monoclonal antibody targeting HER2.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
View more information in the IUPHAR Pharmacology Education Project: trastuzumab
1. Hudziak RM, Shepard HM, Ullrich A. (1989)
Method of treating tumor cells by inhibiting growth factor receptor function.
Patent number: WO1989006692. Assignee: Genentech Inc. Priority date: 12/01/1988. Publication date: 27/07/1989.
2. Mitri Z, Constantine T, O'Regan R. (2012)
The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy.
Chemother Res Pract, 2012: 743193. [PMID:23320171]
3. Paplomata E, Nahta R. (2018)
ABP 980: promising trastuzumab biosimilar for HER2-positive breast cancer.
Expert Opin Biol Ther, 18 (3): 335-341. [PMID:29350568]