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Synonyms: D5v8 | Herceptin® | R-597
trastuzumab is an approved drug (FDA (1998), EMA (2000))
Compound class: Antibody
Comment: Trastuzumab is a humanized IgG1κ monoclonal antibody targeting HER2.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
View more information in the IUPHAR Pharmacology Education Project: trastuzumab
|The use of anti-HER2 monoclonals is covered by patent WO1989006692, in which the clone that produced trastuzumab is 4D5 . Efficacy of the resultant monoclonals was assessed in vitro (for example ELISA for antigen binding and in vitro cellular assays for anti-tumour activity) but no affinity value for the interaction between the antibody and its antigen are provided in the patent.|
|Selectivity at catalytic receptors|
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|Type I RTKs: ErbB (epidermal growth factor) receptor family comments|