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Synonyms: MK 0791 | MK-791 | MK791 | Primaxin®
cilastatin is an approved drug (FDA (1985))
Compound class: Synthetic organic
Comment: Cilastatin (sodium) is an adjunct to treatment with the antibiotic imipenem (PubChem CID 104838). Functions as a dipeptidase inhibitor.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Graham DW, Ashton WT, Barash L, Brown JE, Brown RD, Canning LF, Chen A, Springer JP, Rogers EF. (1987)
Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.
J. Med. Chem., 30 (6): 1074-90. [PMID:3495664]
2. Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ. (1995)
The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.
Antimicrob. Agents Chemother., 39 (7): 1629-31. [PMID:7492120]