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Synonyms: (±)-rolipram | (R,S)-rolipram
Compound class: Synthetic organic
Comment: Rolipram is a a well-characterized PDE4 inhibitor that has been widely used in research to examine the role(s) played by PDE4 in autoimmune and inflammatory diseases [2-3], Alzheimer's disease  and cognition . The INN-assigned preparation of rolipram is a racemic mixture of R-rolipram and S-rolipram. The structure shown here does not specify stereochemistry to represent the mixture. The two stereoisomers are represented on PubChem by CID 448055 and CID 158758, and by the entries on DrugBank linked to in the table above.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. García-Osta A, Cuadrado-Tejedor M, García-Barroso C, Oyarzábal J, Franco R. (2012)
Phosphodiesterases as therapeutic targets for Alzheimer's disease.
ACS Chem Neurosci, 3 (11): 832-44. [PMID:23173065]
2. Huang Z, Mancini JA. (2006)
Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD.
Curr Med Chem, 13 (27): 3253-62. [PMID:17168849]
3. Kumar N, Goldminz AM, Kim N, Gottlieb AB. (2013)
Phosphodiesterase 4-targeted treatments for autoimmune diseases.
BMC Med, 11: 96. [PMID:23557064]
4. Normann C, Berger M. (2008)
Neuroenhancement: status quo and perspectives.
Eur Arch Psychiatry Clin Neurosci, 258 Suppl 5: 110-4. [PMID:18985306]
5. Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. (1997)
Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.
Biochem Biophys Res Commun, 234 (2): 320-4. [PMID:9177268]