Synonyms: baptitoxine | cytisin | cytisinicline | sophorine
Compound class:
Natural product
Comment: Cytisine (INN: cytisinicline) is a naturally occurring phytochemical, found in leguminous plants including species of Laburnum and Cytisus. It interacts with central neuronal α4β2 subtype nicotinic acetylcholine receptors (nACh), with activity as a partial agonist [1-2].
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References |
1. Breining SR. (2004)
Recent developments in the synthesis of nicotinic acetylcholine receptor ligands. Curr Top Med Chem, 4 (6): 609-29. [PMID:14965298] |
2. Holladay MW, Dart MJ, Lynch JK. (1997)
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J Med Chem, 40 (26): 4169-94. [PMID:9435889] |
3. Rigotti NA, Benowitz NL, Prochaska J, Leischow S, Nides M, Blumenstein B, Clarke A, Cain D, Jacobs C. (2023)
Cytisinicline for Smoking Cessation: A Randomized Clinical Trial. JAMA, 330 (2): 152-160. [PMID:37432430] |
4. Rigotti NA, Benowitz NL, Prochaska JJ, Cain DF, Ball J, Clarke A, Blumenstein BA, Jacobs C. (2024)
Cytisinicline for Vaping Cessation in Adults Using Nicotine E-Cigarettes: The ORCA-V1 Randomized Clinical Trial. JAMA Intern Med, 184 (8): 922-930. [PMID:38709500] |