Synonyms: 5'-dTTP | 5-methyl-UTP | ribothymidine triphosphate | thymidine 5'-triphosphate
Compound class:
Metabolite or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G et al.. (2017)
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorg Med Chem Lett, 27 (8): 1840-1847. [PMID:28274633] |
2. Yang G, Wang J, Cheng Y, Dutschman GE, Tanaka H, Baba M, Cheng YC. (2008)
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate. Antimicrob Agents Chemother, 52 (6): 2035-42. [PMID:18391035] |
3. Zelina S, Sheen CW, Radzio J, Mellors JW, Sluis-Cremer N. (2008)
Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine. Antimicrob Agents Chemother, 52 (1): 157-63. [PMID:17967907] |