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Synonyms: antibacterial protein LL-37 | cathelicidin LL 37 (human)
Compound class: Endogenous peptide in human, mouse or rat
Comment: A member of the cathelicidin family of antimicrobial peptides. Induces FPRL-1-mediated chemotaxis of human neutrophils. The mouse orthologue of LL-37 is CRAMP.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. De Yang, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O. (2000)
LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.
J Exp Med, 192 (7): 1069-74. [PMID:11015447]
2. Tomasinsig L, Pizzirani C, Skerlavaj B, Pellegatti P, Gulinelli S, Tossi A, Di Virgilio F, Zanetti M. (2008)
The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.
J Biol Chem, 283 (45): 30471-81. [PMID:18765670]