IL-1 receptor antagonist

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Ligands
IL-1 receptor antagonist (Human)

GtoPdb Ligand ID: 5878

Synonyms: IL-1ra | interleukin-1 receptor antagonist protein | IRAP

Compound class: Endogenous peptide in human, mouse or rat

Comment: A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug anakinra.

Species: Human

References
1. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH et al.. (2009) An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med, 360 (23): 2426-37. [PMID:19494218]
2. Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J. (2009) An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med, 360 (23): 2438-44. [PMID:19494219]
3. Zhang H, Maqsudi S, Rainczuk A, Duffield N, Lawrence J, Keane FM, Justa-Schuch D, Geiss-Friedlander R, Gorrell MD, Stephens AN. (2015) Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. FEBS J, 282 (19): 3737-57. [PMID:26175140]

References

1. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH et al.. (2009)
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.
N Engl J Med, 360 (23): 2426-37. [PMID:19494218]

2. Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J. (2009)
An autoinflammatory disease due to homozygous deletion of the IL1RN locus.
N Engl J Med, 360 (23): 2438-44. [PMID:19494219]

3. Zhang H, Maqsudi S, Rainczuk A, Duffield N, Lawrence J, Keane FM, Justa-Schuch D, Geiss-Friedlander R, Gorrell MD, Stephens AN. (2015)
Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.
FEBS J, 282 (19): 3737-57. [PMID:26175140]