Ligand id: 5889

Name: everolimus

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 15
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 204.66
Molecular weight 957.58
XLogP 4.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S et al.. (2014)
mTOR inhibition improves immune function in the elderly.
Sci Transl Med, 6 (268): 268ra179. [PMID:25540326]
2. Sedrani R, Cottens S, Kallen J, Schuler W. (1998)
Chemical modification of rapamycin: the discovery of SDZ RAD.
Transplant. Proc., 30 (5): 2192-4. [PMID:9723437]