AG 1295   Click here for help

GtoPdb Ligand ID: 5914

Synonyms: AG-1295 | AG1295
Compound class: Synthetic organic
Comment: AG 1295 is a cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 25.78
Molecular weight 234.12
XLogP 3.87
No. Lipinski's rules broken 0
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Canonical SMILES Cc1cc2ncc(nc2cc1C)c1ccccc1
Isomeric SMILES Cc1cc2ncc(nc2cc1C)c1ccccc1
InChI InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Kovalenko M, Gazit A, Böhmer A, Rorsman C, Rönnstrand L, Heldin CH, Waltenberger J, Böhmer FD, Levitzki A. (1994)
Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.
Cancer Res, 54 (23): 6106-14. [PMID:7954456]